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STEROL 14-DEMETHYLASE
Descriptors Found:
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DeCS
Descriptor
English
:
Sterol 14-Demethylase
Descriptor
Spanish
:
Esterol 14-Desmetilasa
Descriptor
Portuguese
:
Esterol 14-Desmetilase
Synonyms
English
:
Sterol 14-Demethylases
Tree Number:
D08.244.453.915.880
D08.811.682.690.708.170.915.880
D08.811.682.690.708.783.880
D12.776.422.220.453.915.880
Definition
English
:
An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl
sterols
such as
lanosterol
. The enzyme acts via the repeated
hydroxylation
of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid.
Sterol 14-demethylase
is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including
ANIMALS
;
PLANTS
; FUNGI; and protozoa.
Entry Combination - descr/qualif
English
:
Sterol 14-Demethylase
/
antagonists & inhibitors
use
14-alpha Demethylase Inhibitors
History Note
English
:
2011
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
54039
Unique Identifier:
D058886
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS